It's a matter of what gear you have and as there are just so many way to skin the beast you have to suck it and see.
A lot of efx loops are not all that smart (IM observation) and maywell be more trouble than they are worth.
Your Amp likely has the 2 inputs , one high and one low,, try using the low input it may work better if the input signal is very hot,, less hiss.
Cheers, Phil.