R&R electric guitar is always distorted in some form or another so you can study this stuff forever but in a sense it all comes down to a basic format.
Input> EQ> Distortion> EQ> distortion> EQ.
In other words every stage in the whole system is open for tweaking in some way whether that be tone shaping or half wave clipping or compression,, pick a name

You can easy show this just by using pedals eq into od then another eq before your main amp and you will be surprised just how effective it is.
All I've really done is study all the tone circuits and found the HiWatt is the best for midrange control.
Mid cut has a big impact on most od pedals and I've found it ever so helpful in sweetening up the distortion.
I recommend the tone circuit as it will be easy to build and will work on almost anything.
The DDC circuit is just a tweaked up headphone box circuit I purchased years back and it had a very good sound but needed more bass for live use.
So I made my own with mods for me.
DDC on its own won't give you instant mojo but it's a good building block.
Depending how hot your pickups are (and type SC or HB) will dictate how much gain and tone shaping you really need to use.
I use lower output SC mainly because I find these far more versatile but If you own one of those insane gain pointy headstock guitars with very high output HB,s you won't have any head room and it will be all square wave with very little dynamics so you might want to back off the gain somewhere.
Big fat pickups will tend to sound like a rockman limiter sound from the 80's through diode distortion circuits like mine so be aware of the limitation of these diode circuits.
Just in case you missed the detail you may note that effectively I use 3 tone shaping circuits in the signal chain.
So don't be fooled,, tone shaping accounts for the missing mojo and tis far more important than the reverse wound diodes you score on ebay.

OK it's not going to win awards but still far cheaper than building a Marshall.
Oh yeah, The tone circuit is not mine, just HiWatt tone circuit which has far more mid control than both F or M circuits.
My only claim is that I worked out it could be used in this manner.
Phil.