In my post above, I meant to add that if you're using a really distorted sound right now, even if you're not sucking out most or all of the mids, you should try backing the gain down in increments and maybe cranking the amp's output louder if needed.
In my first band, the lead singer/rhythm guitarist used an 80-watt Laney 1 x 12 combo and a strat, and he kept up fine with my 100-watt half-stack and the bass player's 350-watt Harkte...using a low-to-medium gain sound, but loud.
In my first band, the lead singer/rhythm guitarist used an 80-watt Laney 1 x 12 combo and a strat, and he kept up fine with my 100-watt half-stack and the bass player's 350-watt Harkte...using a low-to-medium gain sound, but loud.